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Pharmaceutical Discovery, Sep 15, 2005 

Features

Microarrays: Not Just for Genomics Anymore
By Todd Martinsky
This article discusses the impact and implementation of ex situ miniaturization, parallelism and automation on systems biology.

From Genome Sequence to Genome Understanding
By Steve Lombardi
This article describes the manufacturing methods and probe set strategies required to develop microarrays that can be used successfully in different life science research experiments.

Redeveloping Microarray Data Treatment Methods for Transcriptome Study
By Tomokazu Konishi
The author describes a data normalization method for transcriptiome analysis based upon a parametric concept, including the disclosed characteristics of the transcriptome that form the bases of data comparisons.

A Bayesian Approach to Array Image Variability
By Nick Haan
This article briefly reviews current approaches to the analysis of images generated by spotted DNA microarrays and other array-based HTS platforms.

Beyond Expression Analysis: New Applications of High-density DNA Microarrays
By Mark McCormick
Here, the author describes a variety of recent microarray applications aimed at genome-wide comparative genomics.

Substrate Architecture and Function
By Jens Sobek , Ralph Schlapbach
This article describes guidelines and considerations involved in selecting functional surfaces for microarray applications.