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Pharmaceutical Discovery, Oct 1, 2005 
Toxicology Biomarkers in Drug Development

By Timothy P. Ryan , David E. Watson , Brian R. Berridge

Cover Story

Toxicology Biomarkers in Drug Development
By Timothy P. Ryan , David E. Watson , Brian R. Berridge
Now that the industry is immersed in microarray and other genomic technologies, a new strategic direction is needed to bring decision-based toxicology to its full potential. This review focuses on short-term strategies to increase return-on-investment when applying these technologies to better identify candidate toxicology biomarkers.

Features

The Future of Microarray Readers
By Julian White
The author investigates the development of microarray technology and, particularly, the use of microarray readers in healthcare applications. The various elements of current reader technology are reviewed and used to predict the composition of readers for diagnostics and screening.

Metrics and Management

Laboratory Informatics and Financial Performance: A Meeting of Minds
By Gordon W. Logan
In this installment of our Metrics and management column, Gordon Logan examines a subtle but significant approach used by investors to ask not only what money is being spent but also how it is being spent.